Mitglieder (Koordinator*)

M. Baldus (Ffm.)
B. Reif (TUM)*
C. Glaubitz (Ffm.)

• Verbreiterung der Anwendungsbasis
• Vereinheitlichung

Solid-state NMR has evolved in the past two decades into a powerful technique for hypothesis-driven biophysical research and it is an emerging technique for structural biology. Its major strength, besides its applicability to microcrystalline proteins or protein fibers, is based on the possibility to study membrane proteins directly within the lipid bilayer. Despite its rapid development and the increasing availability of modern high field instrumentation in core centers, solid-state NMR is still far away from being a broadly applicable routine method such as liquid-state NMR. (...)

The NMR centers which are equipped with biomolecular solid-state NMR capabilities (i.e. München, Frankfurt, Göttingen, Karlsruhe, Halle, Leipzig, Jülich) will define and implement a set of standard experiments. Such experiments will, e.g., allow doctoral students to rapidly acquire solid-state assignments and experiments to determination the structure of a uniformly isotopically-enriched biomacromolecule in the solid-state. This set of “standard” experiments will be added to a common pulse sequence library that will be shared across centers.